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Merck
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주요 문서

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C5865

Sigma-Aldrich

CD437

≥98% (HPLC), solid

동의어(들):

6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid, AHPN

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About This Item

실험식(Hill 표기법):
C27H26O3
CAS Number:
125316-60-1
Molecular Weight:
398.49
MDL number:
MFCD03106506
UNSPSC 코드:
12352200
PubChem Substance ID:
24724445
NACRES:
NA.77

Quality Level

100

분석

≥98% (HPLC)

양식

solid

불순물

~0.5 mol/mol water

색상

yellow

mp

271.6-276 °C

solubility

DMSO: >10 mg/mL
H2O: insoluble

저장 온도

−20°C

SMILES string

OC(=O)c1ccc2cc(ccc2c1)-c3ccc(O)c(c3)C45CC6CC(CC(C6)C4)C5

InChI

1S/C27H26O3/c28-25-6-5-22(20-1-2-21-11-23(26(29)30)4-3-19(21)10-20)12-24(25)27-13-16-7-17(14-27)9-18(8-16)15-27/h1-6,10-12,16-18,28H,7-9,13-15H2,(H,29,30)

InChI key

LDGIHZJOIQSHPB-UHFFFAOYSA-N

유전자 정보

human ... RARA(5914), RARB(5915), RARG(5916)

관련 카테고리

생화학적/생리학적 작용

CD437 is a retinoic acid receptor (RAR)γ-selective agonist, γ-selective retinoid; potent inducer of apoptosis.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
022M4623V
068K46292
068K46291
068K4629
057K4610

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The infiltration of fat tissue into skeletal muscle, a condition referred to as muscle fatty infiltration or fatty degeneration, is regarded as an irreversible event that significantly compromises the motor function of skeletal muscle. To investigate the effect of retinoic
Fang Tan et al.
Frontiers in microbiology, 10, 2301-2301 (2019-10-28)
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Retinoic acid signaling plays key roles in embryonic development and in maintaining the differentiated status of adult tissues. Recently, the nuclear retinoic acid receptor (RAR) isotypes α, β and γ were found to play specific functions in the expansion and
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A variety of pathways target CDKI p21WAF1/CIP1 expression at transcriptional, post-transcriptional as well as translational levels. We previously found that cell growth suppressing retinoid CD437 enhanced expression of p21WAF1/CIP1 and DNA damage inducible GADD45 proteins in part by elevating their
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문서

Retinoic Acid and Gene Expression

All-trans retinoic acid (RA, ATRA) is a pleiotropic activation factor that regulates genes associated with normal vertebrate cellular processes such as cell differentiation, cell proliferation, apoptosis, and embryonic development.

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