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About This Item
실험식(Hill 표기법):
C24H39NaO5 · xH2O
CAS Number:
Molecular Weight:
430.55 (anhydrous basis)
Beilstein:
3582354
EC Number:
MDL number:
UNSPSC 코드:
12161902
PubChem Substance ID:
NACRES:
NA.75
생물학적 소스
bovine bile
ovine bile
Quality Level
설명
anionic
제품 라인
BioReagent
분석
≥99.0% (HPLC)
양식
powder
분자량
micellar avg mol wt 900-1300
응집 번호
2-3
기술
cell culture | mammalian: suitable
CMC
9-15 mM (20-25°C)
solubility
water: 100 mg/mL, clear, colorless to light yellow
HLB
18
SMILES string
O.[Na+].C[C@H](CCC([O-])=O)C1CCC2C3[C@H](O)CC4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C
InChI
1S/C24H40O5.Na.H2O/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26;;/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29);;1H2/q;+1;/p-1/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-;;/m1../s1
InChI key
MUVVIYFKOVLQHL-RCVKHMDESA-M
유사한 제품을 찾으십니까? 방문 제품 비교 안내
일반 설명
Cholate is a primary bile acid produced from cholesterol in the liver. It is an anionic detergent synthesized from cholesterol in the presence of sterol 12α-hydroxylase (CYP8B1).
애플리케이션
Cholate is a bile acid produced in liver during cholesterol breakdown. Cholate downregulates cholesterol-7-α-hydroxylase (rate-limiting step in bile acid synthesis). Cholate, an anionic detergent, is used alone and in combination with urea to extract and reconstitute membrane proteins and protein complexes.
Sodium cholate hydrate has been used:
- as a bile acid to induce bile acid-responsive (BEAR) transcription system,
- as a component of Campylobacter defined broth (CDB) to test its effect on stress response in Campylobacter jejuni{52
- to test its sensitivity towards the bile acid sensor
생화학적/생리학적 작용
Reduction in 12-α hydroxylase activity leads to low levels of cholic acid in liver disease.
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Aquatic Chronic 3
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
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