Name: Desloratadine
Brand: SIGMA

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About This Item

실험식(Hill 표기법):

C₁₉H₁₉ClN₂

CAS Number:

100643-71-8

Molecular Weight:

310.82

MDL number:

MFCD00871949

UNSPSC 코드:

12352200

PubChem Substance ID:

329798668

NACRES:

NA.32

기술 서비스

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도움 문의

Quality Level

100

분석

≥98% (HPLC)

양식

powder

solubility

DMSO: >10 mg/mL

저장 온도

2-8°C

SMILES string

Clc1ccc2c(CCc3cccnc3\C2=C4\CCNCC4)c1

InChI

1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2

InChI key

JAUOIFJMECXRGI-UHFFFAOYSA-N

유전자 정보

human ... HRH1(3269)

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애플리케이션

Desloratadine has been used to test its effect on embryoid body development in in vitro gastrulation model of P19C5 stem cells. It has also been used as an antihistamine mimic in rats and to treat lung cancer (A549) and glioblastoma (U87) cells in various cellular studies.

생화학적/생리학적 작용

A non-sedating H₁-receptor antagonist, free from antimuscarinic/anticholinergic effects. It has novel antiallergic and anti-inflammatory effects.

Desloratadine is a selective and nonsedating histamine H1 receptor antagonist, an active metabolite of loratadine (Claritin), used to relieve hay fever and allergy symptoms with less drowsiness than other antihistamines; does not significantly inhibits cardiac K+ channels at clinically achievable blood levels. Free from antimuscarinic/anticholinergic effects.