F6627

5-Fluorouracil

≥99% purity (HPLC), powder

• 동의어(들): 2,4-Dihydroxy-5-fluoropyrimidine, 5-FU, 5-Fluoro-2,4(1H,3H)-pyrimidinedione
• 실험식(Hill 표기법): C₄H₃FN₂O₂
• CAS Number: 51-21-8
• Molecular Weight: 130.08
• Beilstein: 127172
• EC Number: 200-085-6
• MDL number: MFCD00006018
• UNSPSC 코드: 12171500
• PubChem Substance ID: 24278439
• NACRES: NA.47

속성

• Product Name: 5-Fluorouracil, ≥99% (HPLC), powder
• 분석: ≥99% (HPLC)
• 양식: powder
• 기술: titration: suitable
• 색상: white
• mp: 282-286 °C (dec.) (lit.)
• solubility: 1 M NH4OH: soluble; DMSO/DMF: soluble; methanol: soluble
• εmax: 7.07 at 265 nm in 0.1 M HCl
• 응용 분야: diagnostic assay manufacturing; hematology; histology
• 저장 온도: room temp
• SMILES string: FC1=CNC(=O)NC1=O
• InChI: 1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
• InChI key: GHASVSINZRGABV-UHFFFAOYSA-N
• 유전자 정보: human ... TYMS(7298)

설명

애플리케이션

5-Fluorouracil has been used to induce apoptosis in cells. It has been used as a chemosensitizing agent.

생화학적/생리학적 작용

A potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase, thus depleting intracellular dTTP pools. It is metabolized to ribonucleotides and deoxyribonucleotides, which can be incorporated into RNA and DNA. Treatment of cells with 5-FU leads to an accumulation of cells in S-phase and has been shown to induce p53 dependent apoptosis.

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H301,H351
• 예방조치 성명서: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Carc. 2
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3