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About This Item
실험식(Hill 표기법):
C22H20N2O5
CAS Number:
Molecular Weight:
392.40
MDL number:
UNSPSC 코드:
12352204
PubChem Substance ID:
NACRES:
NA.77
Product Name
7-Ethyl-10-hydroxycamptothecin, ≥98% (HPLC), powder
생물학적 소스
Artemisia annua
Quality Level
분석
≥98% (HPLC)
양식
powder
solubility
DMSO: 1 mg/mL
저장 온도
−20°C
SMILES string
OC1=CC2=C(CC)C(C3)=C(N=C2C=C1)C(N3C4=O)=CC5=C4COC([C@]5(O)CC)=O
InChI
1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1
InChI key
FJHBVJOVLFPMQE-QFIPXVFZSA-N
애플리케이션
7-Ethyl-10-hydroxycamptothecin has been used:
- to inhibit enterovirus 71 (EV71) (H) infection
- to screen the chemosensitivity of pancreatic adenocarcinoma cells
- as a chemical to study its ability to reverse multidrug resistance (MDR), due to ATP binding cassette (ABC) transporters
생화학적/생리학적 작용
Active metabolite of irinotecan. Inhibitor of topoisomerase I.
Active metabolite of irinotecan. Inhibitor of topoisomerase I.. Gene expression analysis of colon cancer cell lines treated with SN-38 showed differential effects: the majority of affected genes were down-regulated (including, most strongly, genes related to receptor and kinase activity, signal transduction, apoptosis, RNA processing, protein metabolism and transport, cell cycle and transcription. Some of the up-regulated genes were involved in apoptosis, transcription, development and differentiation.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 4 Oral - Repr. 1B - STOT RE 1
표적 기관
Gastro-intestinal system
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.