K1136

Ketorolac tris salt

≥99%, crystalline

• 동의어(들): (±)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid tris salt, Toradol
• 실험식(Hill 표기법): C₁₅H₁₃NO₃ · C₄H₁₁NO₃
• CAS Number: 74103-07-4
• Molecular Weight: 376.40
• MDL number: MFCD00887595
• UNSPSC 코드: 12352202
• PubChem Substance ID: 24278503
• NACRES: NA.77

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 100
• 분석: ≥99%
• 양식: crystalline
• solubility: H₂O: soluble 15 mg/mL, clear, colorless to faintly yellow (stable at least one month at −20 °C.)
• 저장 온도: room temp
• SMILES string: NC(CO)(CO)CO.OC(=O)C1CCn2c1ccc2C(=O)c3ccccc3
• InChI: 1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2
• InChI key: BWHLPLXXIDYSNW-UHFFFAOYSA-N
• 유전자 정보: human ... PTGS1(5742), PTGS2(5743)

설명

애플리케이션

Ketorolac has been used:

• as an intraperitoneal injection in mice to study the effect of ketorolac on expression of c-Fos (a human proto-oncogene) in ARC (arcuate nucleus of the hypothalamus) POMC (proopiomelanocortin) -EGFP (enhanced green fluorescent protein) neurons
• to treat mice in order to show that this treatment does not prevent IL-1β-mediated inhibition of Agouti-related protein (AgRP) secretion from murine hypothalamic explants
• as an analgesic medication to treat rats induced with acute inflammatory joint injury by injecting carrageenan into the ankle

생화학적/생리학적 작용

Ketorolac is a non-steroidal agent that possesses moderate anti-inflammatory activity and is also a potent analgesic. It shows superior analgesic efficacy to that of the opioid analgesics like morphine in patients with moderate to severe postsurgical pain. It inhibits prostaglandin synthesis and platelet aggregation induced by arachidonic acid and collagen. It is a dual COX-1/COX-2 inhibitor.

주의사항

Stable at least 2 years if stored at room temperature.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301,H315,H319,H335
• 예방조치 성명서: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges