Name: Kainic acid monohydrate
Brand: SIGMA

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About This Item

실험식(Hill 표기법):

C₁₀H₁₅NO₄ · H₂O

CAS Number:

58002-62-3

Molecular Weight:

231.25

MDL number:

MFCD00150833

UNSPSC 코드:

12352106

PubChem Substance ID:

24724520

NACRES:

NA.77

기술 서비스

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도움 문의

생물학적 소스

Digenea simplex

Quality Level

100

분석

≥98% (HPLC)

양식

powder

색상

white

solubility

H₂O: >10 mg/mL

저장 온도

2-8°C

SMILES string

O.CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O

InChI

1S/C10H15NO4.H2O/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13;/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15);1H2/t6-,7+,9-;/m0./s1

InChI key

FZNZRJRSYLQHLT-SLGZUKMRSA-N

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애플리케이션

Kainic acid monohydrate has been used:

As a convulsant to induce epileptogenesis and epilepsy in mice.
To stimulate in vitro excitotoxic trauma in spiral ganglion neurons on inner hair cells.
To induce seizures in rat model.
To induce status epilepticus in adult male Wistar rats.

생화학적/생리학적 작용

Agonist for kainate class of ionotropic glutamate receptors.

Ionotropic glutamate receptors form ion channels, and conduct Na⁺ and K⁺ fluxes. The receptors possess an agonist binding site and it encounters a conformational change upon agonist binding to it. Kainate gated channels participate in glutamate-induced excitatory postsynaptic neuronal potential.

Kainic acid monohydrate is an agonist at the kainate class of ionotropic glutamate receptors, which induces seizures and neurodegeneration in vivo and is used to induce experimental epilepsy in rodents and study the mechanisms of excitation-induced neuronal apoptosis.