Name: Dihydrocapsaicin
Brand: SIGMA

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About This Item

실험식(Hill 표기법):

C₁₈H₂₉NO₃

CAS Number:

19408-84-5

Molecular Weight:

307.43

Beilstein:

2815150

MDL number:

MFCD00057794

UNSPSC 코드:

12352200

PubChem Substance ID:

24278532

NACRES:

NA.77

기술 서비스

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도움 문의

Product Name

Dihydrocapsaicin, from Capsicum sp., ≥85%

생물학적 소스

Capsicum sp.

Quality Level

200

분석

≥85%

저장 온도

2-8°C

SMILES string

COc1cc(CNC(=O)CCCCCCC(C)C)ccc1O

InChI

1S/C18H29NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h10-12,14,20H,4-9,13H2,1-3H3,(H,19,21)

InChI key

XJQPQKLURWNAAH-UHFFFAOYSA-N

유전자 정보

human ... TRPV1(7442)
rat ... Trpv4(66026)

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애플리케이션

Dihydrocapsaicin has been used:

as a standard to analyze the level of dihydrocapsaicin in endogenous An2 and capsaicin synthase silenced fruits
as an external standard to determine the variability in capsaicinoid content in different landraces of capsicum
in the activation or ablation of capsaicin-sensitive primary afferents (CSPA) fibres

생화학적/생리학적 작용

Dihydrocapsaicin/8-methyl-N-vanillylnonanamide; N-[−4-hydroxy-3-methoxybenzyl] 8-methylnonanamide (DHC) is an active component of capsaicinoids in chili peppers. DHC is capable of reducing body temperature. Hence it is considered as a pharmaceutical-induced hypothermia (PIH) candidate to treat cardiac arrest (CA) patients. It may possess anti-cancer, anti-inflammation, antioxidant, anti-obesity properties. DHC might help in the reduction of oxidative stress and inflammation in ischemia and reperfusion (I/R) injury. DHC can repress nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway.

VR1 vanilloid receptor agonist.