Name: Methotrexate hydrate
Brand: SIGMA

로그인조직 및 계약 가격 보기

About This Item

실험식(Hill 표기법):

C₂₀H₂₂N₈O₅ · xH₂O

CAS Number:

133073-73-1

Molecular Weight:

454.44 (anhydrous basis)

MDL number:

MFCD00150847

UNSPSC 코드:

12352207

PubChem Substance ID:

24897252

NACRES:

NA.75

기술 서비스

도움이 필요하신가요? 저희 숙련된 과학자 팀이 도와드리겠습니다.

도움 문의

Product Name

Methotrexate hydrate, powder, BioReagent, suitable for cell culture, ≥98% (HPLC)

제품 라인

BioReagent

분석

≥98% (HPLC)

양식

powder

기술

cell culture | mammalian: suitable

solubility

H₂O: insoluble

항생제 활성 스펙트럼

neoplastics
parasites

동작 모드

enzyme | inhibits

저장 온도

−20°C

SMILES string

[H]O[H].CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O

InChI

1S/C20H22N8O5.H2O/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27);1H2/t13-;/m0./s1

InChI key

FPJYMUQSRFJSEW-ZOWNYOTGSA-N

유전자 정보

human ... DHFR(1719)

유사한 제품을 찾으십니까? 방문 제품 비교 안내

애플리케이션

Methotrexate hydrate has been used:

as a dihydrofolate (DHFR) inhibitor in sphere forming assay culture
as a component of dulbecco′ modified Eagle′s medium (DMEM) for selection of transfected cells
in viability and co-culture assays

Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems.

Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.

Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.