M9695

Matrix Metalloproteinase-12, Catalytic Domain human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), buffered aqueous glycerol solution

• 동의어(들): MMP-12, Macrophage Elastase
• MDL number: MFCD02688053
• UNSPSC 코드: 12352202
• NACRES: NA.32

속성

• 재조합: expressed in E. coli
• Quality Level: 200
• 분석: ≥95% (SDS-PAGE)
• 양식: buffered aqueous glycerol solution
• 분자량: calculated mol wt 20.3 kDa
• UniProt 수납 번호: P39900
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... MMP12(4321)

설명

일반 설명

Matrix metalloproteinase-12 (MMP-12) is also called as macrophage metalloelastase and is secreted by inflammatory macrophages. It is synthesized as a zymogen and then activated by cleaving the propeptide domain. The MMP-12 gene is localized on chromosome 11.

생화학적/생리학적 작용

MMP-12 degrades general matrix components and may have a role in processes such as host defense, cell proliferation, and protein turnover as well as tissue remodeling.

Matrix metalloproteinase-12 (MMP-12) breaks down proteoglycans, collagen type IV and laminin. Its main substrate is elastin.

단위 정의

One unit equals 100 pmol/min at 37 °C using the colorimetric thiopeptolide Ac-Pro-Leu-Gly-S-Leu-Leu-Gly-OEt as substrate.

물리적 형태

Solution in 50 mM Tris, 5 mM calcium chloride, 500 mM sodium chloride, 20 μM zinc chloride, 0.5% Brij^® L23, and 30% glycerol, pH 9.5.

법적 정보

Brij is a registered trademark of Croda International PLC

안전성 정보

• 유해 및 위험 성명서: H412
• 예방조치 성명서: P273 - P501
• Hazard Classifications: Aquatic Chronic 3
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Gloves, multi-purpose combination respirator cartridge (US)