N4148

S-Nitrosoglutathione

≥97%

• 동의어(들): GSNO, SNOG
• 실험식(Hill 표기법): C₁₀H₁₆N₄O₇S
• CAS Number: 57564-91-7
• Molecular Weight: 336.32
• MDL number: MFCD00214341
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278587
• NACRES: NA.32

속성

• Quality Level: 200
• 분석: ≥97%
• 양식: powder
• solubility: water: soluble 19.60-20.40 mg/mL
• 저장 온도: −20°C
• SMILES string: N[C@@H](CCC(=O)N[C@@H](CSN=O)C(=O)NCC(O)=O)C(O)=O
• InChI: 1S/C10H16N4O7S/c11-5(10(19)20)1-2-7(15)13-6(4-22-14-21)9(18)12-3-8(16)17/h5-6H,1-4,11H2,(H,12,18)(H,13,15)(H,16,17)(H,19,20)/t5-,6-/m0/s1
• InChI key: HYHSBSXUHZOYLX-WDSKDSINSA-N

설명

일반 설명

S-Nitrosoglutathione (GSNO) is an endogenous nitrogen oxide and is highly distributed in extracellular fluids of the lung and brain.

애플리케이션

S-Nitrosoglutathione (GSNO) has been used:

• as a standard in reversed phase chromatography coupled to chemical vapour generation and atomic fluorescence detector (RPC-CVGAFS) and reversed phase chromatography fluorimetric (RPC-FD).
• as a standard in spectrophotometric and high-performance liquid chromatography (HPLC) assay.

생화학적/생리학적 작용

S-Nitrosoglutathione (GSNO) inhibits the activity of sarcoplasmic reticulum-bound creatine kinase in rabbit skeletal muscle and eventually reduces ATP driven Ca²⁺ uptake in sarcoplasmic reticulum vesicles. GSNO in airway cells relaxes airway smooth muscle and enhances airway ciliary motility. It also blocks airway epithelial amiloride-sensitive sodium transport while stimulating calcium-dependent epithelial chloride transport and induces neutrophilic apoptosis. In addition, it also has antimicrobial activity. GSNO concentration is low in cystic fibrosis (CF) airway. It is an NO donor, acts as a smooth muscle relaxant, vasodilator and inhibits platelet activation in vivo.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves