N8509

N-Nitroso-N-ethylurea

Bulk package

• 동의어(들): ENU, N-Ethyl-N-nitrosourea
• 실험식(Hill 표기법): C₃H₇N₃O₂
• CAS Number: 759-73-9
• Molecular Weight: 117.11
• EC Number: 212-072-2
• MDL number: MFCD00053635
• UNSPSC 코드: 12352102
• PubChem Substance ID: 24897681
• NACRES: NA.25

속성

• Quality Level: 100
• 양식: powder
• 포함: aqueous acetic acid as stabilizer
• 저장 온도: −20°C
• SMILES string: CCN(N=O)C(N)=O
• InChI: 1S/C3H7N3O2/c1-2-6(5-8)3(4)7/h2H2,1H3,(H2,4,7)
• InChI key: FUSGACRLAFQQRL-UHFFFAOYSA-N

설명

애플리케이션

• Genetic determinants of blood pressure and heart rate identified through ENU-induced mutagenesis with automated meiotic mapping.: This study identifies genetic factors affecting blood pressure and heart rate using N-ethyl-N-nitrosourea (ENU)-induced mutagenesis. The research utilizes automated meiotic mapping to reveal the genetic underpinnings of these cardiovascular traits, providing insights that could inform therapeutic targets (Teixeira et al., 2024).


• Clonality, trafficking, and molecular alterations among Hprt mutant T lymphocytes isolated from control mice versus mice treated with N-ethyl-N-nitrosourea.: This study examines the effects of ENU on T lymphocyte clonality and trafficking in mice. The findings provide insights into the mutagenic and immunological impacts of ENU, contributing to our understanding of chemical-induced mutations (Judice et al., 2023).


• Adopting duplex sequencing technology for genetic toxicity testing: A proof-of-concept mutagenesis experiment with N-ethyl-N-nitrosourea (ENU)-exposed rats.: This proof-of-concept study integrates duplex sequencing technology to test genetic toxicity in rats exposed to ENU. The results demonstrate the feasibility and effectiveness of this approach in detecting mutagenic effects, highlighting its potential for genetic toxicity assessment (Smith-Roe et al., 2023).

생화학적/생리학적 작용

DNA alkylating agent that is carcinogenic in many animal species. Induces benign and malignant tumors of numerous types, including the nervous tissue, stomach, esophagus, pancreas, respiratory tract, intestine, lymphoreticular tissues, skin, and kidney.

포장

Weight on dry basis.

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H301,H312 + H332,H350,H360
• 예방조치 성명서: P202 - P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 3 Oral - Carc. 1B - Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges