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About This Item
실험식(Hill 표기법):
C17H19N3O3S
CAS Number:
Molecular Weight:
345.42
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
Product Name
Omeprazole, solid
양식
solid
Quality Level
색상
white
solubility
H2O: 0.5 mg/mL
DMSO: >19 mg/mL
ethanol: 4.5 mg/mL
주관자
AstraZeneca
저장 온도
2-8°C
SMILES string
COc1ccc2[nH]c(nc2c1)S(=O)Cc3ncc(C)c(OC)c3C
InChI
1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)
InChI key
SUBDBMMJDZJVOS-UHFFFAOYSA-N
유전자 정보
human ... ABCB1(5243), ATP4A(495), ATP4B(496), CYP1A2(1544)
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일반 설명
Omeprazole is a benzimidazole derivative, a weak base and is lipophilic in nature. This compound is pH sensitive and does not exists in its original form at low pH.
애플리케이션
Omeprazole has been used as an atypical cytochrome P450 (CYP) 1A2 inducer in Dulbecco′s modified eagle′s medium (serum free) to study the effects of inducers on CYP activities in human hepatocytes and also to compare with other classical aryl hydrocarbon receptor ligands.
생화학적/생리학적 작용
Omeprazole binds covalently to proton pump (H+, K+-ATPase) and inhibits gastric secretion. It is useful in ameliorating the effects of peptic oesophagitis, duodenal and gastric ulcer. Omeprazole is preferred over antagonists of histamine H2-receptor and ranitidine for its higher efficiency. It is also useful in treating Zollinger-Ellison syndrome.
특징 및 장점
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
주의사항
Hygroscopic, photosensitive
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
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