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About This Item
실험식(Hill 표기법):
C10H15N5O3
CAS Number:
Molecular Weight:
253.26
MDL number:
UNSPSC 코드:
51102829
PubChem Substance ID:
NACRES:
NA.76
양식
powder
Quality Level
solubility
0.02 M potassium phosphate: soluble 2 mg/mL
항생제 활성 스펙트럼
viruses
동작 모드
DNA synthesis | interferes
enzyme | inhibits
SMILES string
NC1=NC(=O)c2ncn(CCC(CO)CO)c2N1
InChI
1S/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)2-1-6(3-16)4-17/h5-6,16-17H,1-4H2,(H3,11,13,14,18)
InChI key
JNTOCHDNEULJHD-UHFFFAOYSA-N
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관련 카테고리
애플리케이션
Penciclovir is a selective antiherpesvirus agent, particularly against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) and varicella-zoster virus (VZV).
생화학적/생리학적 작용
Penciclovir is converted to its active form, penciclovir triphosphate, by cellular kinases. It inhibits viral DNA polymerase by competing with deoxyguanosine triphosphate. It inhibits DNA synthesis of virus-infected cells. Penciclovir has in vitro activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). It does not inhibit DNA synthesis in non-infected cells. Mode of resistance is via qualitative changes in viral thymidine kinase or DNA polymerase.
기타 정보
Keep container tightly closed in a dry and well-ventilated place.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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