P0122

Pifithrin-μ

≥97% (HPLC), solid

• 동의어(들): 2-Phenylethynesulfonamide, PFTμ
• 실험식(Hill 표기법): C₈H₇NO₂S
• CAS Number: 64984-31-2
• Molecular Weight: 181.21
• MDL number: MFCD00181531
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24724568
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 양식: solid
• 저장 조건: desiccated
• solubility: DMSO: soluble >10 mg/mL, clear; H₂O: insoluble
• 저장 온도: 2-8°C
• SMILES string: NS(=O)(=O)C#Cc1ccccc1
• InChI: 1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11)
• InChI key: ZZUZYEMRHCMVTB-UHFFFAOYSA-N

설명

애플리케이션

Pifithrin-μ has been used:

• to treat microglial cell line to analyse its neuroprotective effect on M1-like and M2-like phenotype
• as heat shock protein (HSP)-70 inhibitor, to treat transfected Marc-145 cells
• to inhibit heat shock cognate 70 (Hsc70) to elucidate heat shock chaperones mouse embryonic stem cells

생화학적/생리학적 작용

Pifithrin-μ is an inhibitor of p53 binding and anti-apoptotic, which directly inhibits p53 binding to mitochondria as well as to Bcl-xL and Bcl-2 proteins.

Pifithrin-μ is an inhibitor of p53 binding and anti-apoptotic, which directly inhibits p53 binding to mitochondria as well as to Bcl-xL and Bcl-2 proteins. PFTμ rescues cells from lethal γ-irradiation-induced cell death. Because pifithrin-μ shuts down only the p53-mitochondrial pathway without affecting the transcriptional functions of p53, it is superior to pifithrin-α.

Pifithrin-μ(PFT-μ) has neuroprotective capabilities against cell death in a preclinical model of hypoxia-ischemia (HI)-induced neonatal encephalopathy. It inhibits nuclear factor-ΙB (NF-ΙB) pathway by inhibiting the interaction of molecular chaperone heat shock protein (HSP)-70 with its substrates.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves