PZ0135

PHA-543613

≥98% (HPLC)

• 동의어(들): N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide
• 실험식(Hill 표기법): C₁₅H₁₇N₃O₂
• CAS Number: 478149-53-0
• Molecular Weight: 271.31
• UNSPSC 코드: 51111800
• PubChem Substance ID: 329823720
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to off-white
• solubility: DMSO: ≥20 mg/mL
• 저장 온도: room temp
• SMILES string: O=C(N[C@H]1CN2CC[C@H]1CC2)c3cc4ccoc4cn3
• InChI: 1S/C15H17N3O2/c19-15(12-7-11-3-6-20-14(11)8-16-12)17-13-9-18-4-1-10(13)2-5-18/h3,6-8,10,13H,1-2,4-5,9H2,(H,17,19)/t13-/m0/s1
• InChI key: IPKZCLGGYKRDES-ZDUSSCGKSA-N
• 유전자 정보: human ... CHRNA7(1139)

설명

애플리케이션

PHA-543613 has been used to study its effect on recognition memory and neurovascular coupling (NVC) response in β-amyloid (Aβ) 25-35-treated mice. It has also been used to study its effect on Aβ25-35-induced receptor alteration and cognitive impairment in mice.

생화학적/생리학적 작용

PHA-543613 exhibits rapid brain penetration property.

PHA-543613 is a potent selective α7 nAChR agonist. Nicotinic acetylcholine receptors are ligand-gated ion channels activated by nicotine, expressed in multiple tissues, with high functional expression in brain. The homomeric subtype α7 is a potential therapeutic target for cognitive deficits in schizophrenia and Alzheimer′s disease. PHA-543613 is active in both in vitro (binding, calcium flux, patch-clamp) and in vivo (auditory gating, novel object recognition) assays.

PHA-543613 is a potent selective a7 nAChR agonist.

특징 및 장점

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable