R0283

Ropivacaine hydrochloride monohydrate

≥98% (HPLC)

• 동의어(들): (2S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinecarboxamide hydrochloride monohydrate, (S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride monohydrate, Naropin hydrochloride monohydrate
• 실험식(Hill 표기법): C₁₇H₂₆N₂O · HCl · H₂O
• CAS Number: 132112-35-7
• Molecular Weight: 328.88
• MDL number: MFCD00946578
• UNSPSC 코드: 12352203
• PubChem Substance ID: 329823983
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 광학 활성: [α]/D -9 to -12, c = 1 in methanol
• 저장 조건: desiccated
• 색상: white to off-white
• solubility: H₂O: 5 mg/mL, clear
• 주관자: AstraZeneca
• 저장 온도: 2-8°C
• SMILES string: O.Cl.CCCN1CCCC[C@H]1C(=O)Nc2c(C)cccc2C
• InChI: 1S/C17H26N2O.ClH.H2O/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;;/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H;1H2/t15-;;/m0../s1
• InChI key: VSHFRHVKMYGBJL-CKUXDGONSA-N

설명

일반 설명

Ropivacaine has lidocaine-related structure with tertiary amine side chains. It is a pure S(-)enantiomer with a propyl group on the piperidine nitrogen atom.

애플리케이션

Ropivacaine hydrochloride monohydrate has been used as an analyte in tandem mass spectrometry and as an amide-based local anaesthetic to test its effect on breast cancer cell methylation.

생화학적/생리학적 작용

Local anaesthetic with less cardiotoxicity than bupivacaine.

Local anaesthetic with less cardiotoxicity than bupivacaine; causes reversible blockade of impulse propagation along nerve fibres by preventing the inward movement of sodium ions through the cell membrane of the nerve fibers.

Ropivacaine less lipophilic as compared with bupivacaine. It is metabolized in the liver by the enzyme cytochrome P4501A2. Ropivacaine elicits less central nervous system (CNS) toxicity and is used as a local anaesthetic during postoperative and labour pain.

특징 및 장점

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS05
• 신호어: Danger
• 유해 및 위험 성명서: H318
• 예방조치 성명서: P280 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable