S1950

STX64

≥98% (HPLC)

• 동의어(들): 667 Coumate, BN 83495
• 실험식(Hill 표기법): C₁₄H₁₅NO₅S
• CAS Number: 288628-05-7
• Molecular Weight: 309.34
• MDL number: MFCD12912443
• UNSPSC 코드: 51111800
• PubChem Substance ID: 329824496
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white
• solubility: DMSO: >20 mg/mL
• 저장 온도: 2-8°C
• SMILES string: NS(=O)(=O)Oc1ccc2C3=C(CCCCC3)C(=O)Oc2c1
• InChI: 1S/C14H15NO5S/c15-21(17,18)20-9-6-7-11-10-4-2-1-3-5-12(10)14(16)19-13(11)8-9/h6-8H,1-5H2,(H2,15,17,18)
• InChI key: DSLPMJSGSBLWRE-UHFFFAOYSA-N
• 유전자 정보: human ... STS(412)

설명

생화학적/생리학적 작용

STX64 is a potent, irreversible inhibitor of steroid sulfatase.

STX64 is a potent, irreversible inhibitor of steroid sulfatase. Inhibition of steroid sulfatase (STS), the enzyme responsible for the hydrolysis of steroid sulfates, represents a potential novel treatment for postmenopausal women with hormone-dependent breast cancer. Estrone and DHEA are formed by this sulfatase pathway and can be converted to steroids (estradiol and androstenediol, respectively), which have potent estrogenic properties. STX64 (667 coumate) is a potent tricylic coumarin-based sulfamate that irreversibly inhibits STS activity (IC₅₀ = 8 nM in a placental microsomal assay system). Estrone sulfamate (EMATE) is also a potent STS inhibitor, but has estrogenic activity.

특징 및 장점

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)