Pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) is encoded by the gene mapped to human chromosome 18q21.33. The encoded protein belongs to the PHLPP family and is characterized with a PH domain followed by region of leucine-rich repeats (LRR), a PP2C phosphatase domain and a C-terminal PDZ ligand. PHLPP1 has two alternatively spliced transcript variants encoding different isoforms namely PHLPP1α with 1205 amino acids and PHLPP1β with 1717 amino acids. PHLPP1 is expressed in cytosolic, nuclear and membrane fraction of cells.

PHLPP1 (NP_919431, 24-58)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human PHLPP1.

PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1) catalyzes the dephosphorylation of serine/threonine-protein kinases AKT2 and AKT3. The encoded protein might act as a tumor suppressor. Loss of gene expression is associated with the development of colon cancers. Overexpression of the gene has been observed in skeletal muscles of Type 2 diabetic patients. Thus, inhibition of PHLPP1 might enhance Akt2 activity and can be considered as a potent therapeutic target for the type II diabetes. Inhibition PHLPP1 through DNA methylation leads to the development of melanoma.

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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