SAB3500095

Anti-JMJD2A antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• 동의어(들): Anti-Jumonji domain-containing protein 2A, Anti-KDM4A, Anti-Lysine-specific demethylase 4A
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 종 반응성: mouse, rat, human
• 기술: immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• NCBI 수납 번호: CAH71021

설명

면역원

JMJD2A antibody was raised against a 14 amino acid peptide from near the center of human JMJD2A.

특징 및 장점

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표적 설명

Members of the Jumonji domain 2 (JMJD2) family contain a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. The first member of this group, JMJD2A, is widely expressed in human tissues and cell lines and functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. JMJD2A can also form a complex with the androgen receptor (AR), a transcription factor that is pivotal for the development of prostate cancer. Overexpression of JMJD2A stimulates AR function and this stimulation is dependent on JMJD2A catalytic activity, suggesting that JMJD2A might be a critical protein with roles in cell proliferation and oncogenesis.

결합

The action of this antibody can be blocked using blocking peptide SBP3500095.

물리적 형태

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable