SAB4300468
Anti-PTK2B (Ab-402) antibody produced in rabbit
affinity isolated antibody
동의어(들):
Anti-CADTK antibody produced in rabbit, Anti-CAKB antibody produced in rabbit, Anti-FADK2 antibody produced in rabbit, Anti-FAK2 antibody produced in rabbit, Anti-PTK2B protein tyrosine kinase 2 beta antibody produced in rabbit
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About This Item
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
~116 kDa
종 반응성
rat, mouse, human
농도
1 mg/mL
일반 설명
PTK2B/ Pyk2 (proline-rich tyrosine kinase 2β) is a non receptor protein kinase that belongs to the focal adhesion kinase family. It is also known as FAK2 (focal adhesion kinase 2), RAFTK (related adhesion focal tyrosine kinase) and CAKB (cell adhesion kinase beta). Its expression is confined to the endothelium, central nervous system and hematopoietic lineages. It is located on human chromosome 8p21.1.
면역원
Peptide sequence around aa. 400-404 (D-I-Y-A-E), according to the protein PTK2B.
애플리케이션
Anti-PTK2B (Ab-402) antibody has been used in immunohistofluorescence.
생화학적/생리학적 작용
Protein tyrosine kinase 2β(PTK2B) participates in the pathogenesis of Alzheimer′s disease (AD). It induces tumor progression in multiple myeloma. It helps in the multiplication, movement and survival of cells.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
표적 설명
Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.
물리적 형태
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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