추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen 265 kDa
종 반응성
rat, human, mouse
농도
~1 mg/mL
기술
ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... ACACA(31)
일반 설명
Anti-ACC1 Antibody detects endogenous levels of total ACC1 protein.
Acetyl-CoA carboxylase 1 (ACC1) is expressed in adipose tissue, liver, and lactating mammary gland. It is a cytosolic enzyme. The ACC1 gene is mapped to human chromosome 17q12. It comprises biotin carboxylase (BC), carboxyl transferase (CT), and biotin carboxyl carrier protein (BCCP) domains. The BC and CT domains are bridged together through an interaction domain (BT) and a non-catalytic central domain region (CD). The ACC1 gene encompasses three distinct promoter (PI, PII, and PIII) regions.
면역원
The antiserum was produced against synthesized peptide derived from human ACC1.
Immunogen Range: 46-95
Immunogen Range: 46-95
애플리케이션
Anti-ACC1 antibody produced in rabbit has been used in immunoblotting at a dilution 1:500 and immunohistochemistry (1:50 dilution).
생화학적/생리학적 작용
Acetyl-CoA carboxylase 1 (ACC1) mediates the carboxylation of acetyl-CoA to form malonyl-CoA in an ATP-dependent manner. It plays a key role in lipogenesis, and its inhibition is regarded as one of the ways to target fatty acid synthesis, especially in metabolic disorders and metabolic syndromes. Haploinsufficiency of ACC1 gene impacts regular fatty acid metabolism. This, in turn, may lead to pathologies associated with infantile encephalitic illness and seizures.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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