SAB4702109

Monoclonal Anti-CD41/CD61 (PAC-1 epitope) FITC produced in mouse

• 동의어(들): GP3A, GPIIb, GPalpha IIb, GT, Integrin alpha-Iib, platelet GPIIIa, platelet GPIIb
• UNSPSC 코드: 12352203

속성

• 결합: FITC conjugate
• Quality Level: 100
• 항체 생산 유형: primary antibodies
• 클론: PAC-1, monoclonal
• 양식: buffered aqueous solution
• 종 반응성: human
• 기술: flow cytometry: suitable
• 동형: IgMκ
• 저장 온도: 2-8°C
• 타겟 번역 후 변형: unmodified

설명

일반 설명

CD41 (platelet glycoprotein IIb, integrin alpha IIb) is composed of two subunits (120 kDa transmembrane alpha chain and 23 kDa extracellular beta chain) and interacts with CD61 (platelet glycoprotein IIIa, integrin beta 3) in the presence of calcium to form a functional adhesive protein receptor. CD41/CD61 complex is one of the earliest markers of the megakaryocytic lineage. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin, and it is involved in platelet aggregation.

특이성

The mouse monoclonal antibody PAC-1 recognizes an extracellular activation-induced conformational epitope PAC-1 on CD41/CD61 complex (gpIIb/IIIa), also known as integrin alpha IIb beta 3, a receptor which mediates platelet aggregation.

면역원

Human platelets

물리적 형태

Stabilizing Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

제조 메모

Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

저장 및 안정성

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

기타 정보

The antibody solution should be gently mixed before use.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable