Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif. In response to increased Ca(2+ levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation. In response to increased Ca(2+ levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion. Dephosphorylates heat shock protein HSPB1 (By similarity. Dephosphorylates and activates transcription factor NFATC1. In response to increased Ca(2+ levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. May dephosphorylate CRTC2 at ′Ser-171′ resulting in CRTC2 dissociation from 14-3-3 proteins. Dephosphorylates transcription factor TFEB at ′Ser-211′ following Coxsackievirus B3 infection, promoting nuclear translocation.

A synthetic peptide corresponding to a sequence within amino acids 422-521 of human Calcineurin A (Q08209).

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

WB