생물학적 소스
rabbit
Quality Level
material
colorless
클론
4E5F1, monoclonal
양식
liquid
분자량
110 kDa
종 반응성
human
농도
1.20 mg/mL
기술
immunohistochemistry: 1:50 - 1:200
western blot: 1:500 - 1:1000
색상
colorless
일반 설명
The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome. [provided by RefSeq, Apr 2016]
면역원
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PMS2 (P54278).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
애플리케이션
WB, IHC
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
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