SML0177

AUDA

≥98% (HPLC)

• 동의어(들): 12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid
• 실험식(Hill 표기법): C₂₃H₄₀N₂O₃
• CAS Number: 479413-70-2
• Molecular Weight: 392.58
• MDL number: MFCD12912267
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825206
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: ≥10 mg/mL at warmed to 60 °C
• 저장 온도: −20°C
• SMILES string: OC(=O)CCCCCCCCCCCNC(=O)NC12C[C@@H]3C[C@@H](C[C@@H](C3)C1)C2
• InChI: 1S/C23H40N2O3/c26-21(27)10-8-6-4-2-1-3-5-7-9-11-24-22(28)25-23-15-18-12-19(16-23)14-20(13-18)17-23/h18-20H,1-17H2,(H,26,27)(H2,24,25,28)/t18-,19+,20-,23-
• InChI key: XLGSEOAVLVTJDH-UKBVAGSOSA-N

설명

애플리케이션

AUDA has been used in the inhibition of epoxide hydrolase in human macrophages and in inhibition of tumor necrosis factor α (TNF-α)- induced phosphorylation in human aortic smooth muscle cells.

AUDA may be used in soluble epoxide hydrolase-mediated cell signaling studies.

생화학적/생리학적 작용

AUDA is a potent inhibitor of soluble epoxide hydrolase

Inhibition of soluble epoxide hydrolase by AUDA inhibits the metabolism of epoxyeicosatrienoic acids (EETs) and protects end-organs against the damaging effects of salt-sensitive hypertension. AUDA also renders protection against myocardial ischemia-reperfusion injury and cerebral ischemia.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable