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About This Item
실험식(Hill 표기법):
C5H10N2O7P2·H2O
CAS Number:
Molecular Weight:
290.10
MDL number:
UNSPSC 코드:
12352204
PubChem Substance ID:
NACRES:
NA.77
Quality Level
분석
≥98% (HPLC)
양식
powder
저장 조건
desiccated
protect from light
색상
white to beige
solubility
H2O: ≥2 mg/mL
저장 온도
2-8°C
SMILES string
O.OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O
InChI
1S/C5H10N2O7P2.H2O/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);1H2
InChI key
FUXFIVRTGHOMSO-UHFFFAOYSA-N
유사한 제품을 찾으십니까? 방문 제품 비교 안내
애플리케이션
Zoledronic acid monohydrate has been used:
- as an inhibitor for cell proliferation in glioblastoma, breast cancer tumor and prostate cancer cell line LAPC4
- as a conjugate with D,L-lactide 75: glycolide 25 (PLGA) to analyze its bone formation functionality in distal femur
- as an inhibitor for farnesyl diphosphate synthase enzyme in glioblastoma cells
생화학적/생리학적 작용
Zoledronic acid (zoledronate) is a bisphosphonate bone resorption inhibitor, an inhibitor of farnesyl diphosphate (FPP) synthase which results in downstream inhibition of osteoclast activity and reduced bone resorption and turnover. It has been used to treat postmenopausal osteoporosis, Paget′s disease, hypercalcemia, and along with cancer chemotherapy to treat bone damage caused by cancer that has spread to the bones.
Zoledronic acid (zoledronate) is a bone resorption inhibitor, an inhibitor of farnesyl diphosphate synthase
제조 메모
This product is extremely unstable in solution and should be used shortly after reconstitution. If storage of the solution is necessary it can be held at 2-8ºC for no more than 24 hours.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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