SML1005

NSC 617145

≥98% (HPLC)

• 동의어(들): (2,3-Propandiyl-bis(2,3-dichloro)maleimide, 1,1′-(2,2-Dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-Pyrrole-2,5-dione, NSC-617145, SID 487795
• 실험식(Hill 표기법): C₁₃H₁₀Cl₄N₂O₄
• CAS Number: 203115-63-3
• Molecular Weight: 400.04
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to light brown
• solubility: DMSO: 3 mg/mL, clear (warmed)
• 저장 온도: 2-8°C
• SMILES string: ClC1=C(C(=O)N(C1=O)CC(CN2C(=O)C(=C(C2=O)Cl)Cl)(C)C)Cl
• InChI: 1S/C13H10Cl4N2O4/c1-13(2,3-18-9(20)5(14)6(15)10(18)21)4-19-11(22)7(16)8(17)12(19)23/h3-4H2,1-2H3
• InChI key: PCOXPBOKDABARQ-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

NSC 617145 has an IC₅₀ value of 230nM.

NSC 617145 is a potent and cell-permeable inhibitor of Werner syndrome helicase (WRN) that causes accumulation of double-strand breaks (DSB) and chromosomal abnormalities in cancer cells.

NSC 617145 is a potent and cell-permeable inhibitor of Werner syndrome helicase (WRN).

특징 및 장점

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안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable