SML1232

cGAMP sodium salt

≥98% (HPLC)

• 동의어(들): 3′3′-cGAMP sodium salt, Cyclic AMP-GMP sodium salt, c-GMP-AMP sodium salt, cyclic GMP-AMP sodium salt
• 실험식(Hill 표기법): C₂₀H₂₄N₁₀O₁₃P₂ · xNa⁺
• CAS Number: 849214-04-6
• Molecular Weight: 674.41 (free acid basis)
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825735
• NACRES: NA.77

속성

• 설명: contains 0.5μmol of powder (approx. 0.335mg)
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• 저장 온도: −20°C
• SMILES string: O=C1N=C(N)NC2=C1N=CN2[C@H](O3)[C@H](O)[C@H](OP4(O)=O)[C@H]3COP(O)(O[C@H]5[C@@H](O)[C@H](N6C=NC7=C6N=CN=C7N)O[C@@H]5CO4)=O.C

설명

애플리케이션

cGAMP sodium salt has been used in cGAS-cGAMP Activity Assay.

생화학적/생리학적 작용

Cyclic AMP-GMP (cGAMP) is a bacterial second messenger.

Cyclic AMP-GMP (cGAMP) is one of several naturally occurring cyclic dinucleotides that act as a bacterial second messengers to regulate important signaling mechanisms in prokaryotes that control bacterial survival, adhesion, colonization, biofilm formation, and virulence factors production. In cholera c-AMP-GMP promotes intestinal colonization by down-regulating chemotaxis. During infections bacterial cGAMP is bound by host STING (stimulator of interferon genes) activating innate immune responses leading to expression of interferon genes.

cGAMP induces the formation of cytokines (interferon-β, interferon-γ), activation of dendritic cells and CD8⁺ T cell cross priming. Through this action, it promotes innate immune response. cGAMP possesses antitumor activity and is prefered for immunotherapy in cancer treatment.

제조 메모

Cyclic AMP-GMP is soluble in water and aqueous buffers (> 10 mM, limits have not been determined).

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable