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About This Item
실험식(Hill 표기법):
C20H19ClFNO4
CAS Number:
Molecular Weight:
391.82
MDL number:
UNSPSC 코드:
12352202
PubChem Substance ID:
NACRES:
NA.77
Quality Level
분석
≥98% (HPLC)
양식
powder
광학 활성
[α]/D -100 to -110°, c = 1 in methanol
색상
white to beige
solubility
DMSO: 20 mg/mL, clear
저장 온도
2-8°C
SMILES string
CC(C1=CC=C2C([C@H](NC(C3=CC=C(F)C(Cl)=C3)=O)[C@H](O)C(C)(C)O2)=C1)=O
InChI
1S/C20H19ClFNO4/c1-10(24)11-5-7-16-13(8-11)17(18(25)20(2,3)27-16)23-19(26)12-4-6-15(22)14(21)9-12/h4-9,17-18,25H,1-3H3,(H,23,26)/t17-,18-/m0/s1
InChI key
XLIIRNOPGJTBJD-ROUUACIJSA-N
생화학적/생리학적 작용
Tonabersat (SB-220453) exhibits anticonvulsant property. It is a member of the family of novel benzoylamino-benzopyran compounds. Tonabersat is used as a therapeutic for trigeminal nerve-induced neurovascular reflexes. In addition, it acts as a putative migraine prophylactic agent containing an unique stereospecific binding site in the brain.
Tonabersat is a potent inhibitor of neuronal-glial gap junctions in trigeminal ganglion that inhibits cortical spreading depression (CSD) and neurogenic inflammation in animal models of migraine.
Tonabersat is a potent inhibitor of neuronal-glial gap junctions.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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