SML1554

S3QEL 2

• 동의어(들): 1-(3,4-Dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
• 실험식(Hill 표기법): C₁₉H₂₅N₅
• CAS Number: 890888-12-7
• Molecular Weight: 323.44
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 양식: powder
• Quality Level: 100
• 색상: white to beige
• solubility: DMSO: 5 mg/mL, clear
• 저장 온도: −20°C

설명

생화학적/생리학적 작용

S3QEL 2 is a selective inhibitor of superoxide production from the outer Q-binding site of mitochondrial respiratory complex site III (IIIQo) without altering oxidative phosphorylation.

S3QEL 2 is a selective inhibitor of superoxide production from the outer Q-binding site of mitochondrial respiratory complex site III (IIIQo) without altering oxidative phosphorylation. Site IIIQo is the primary source of mitochondrial reactive oxygen species (ROS) and has been implicated in a broad range of ROS-mediated signaling and pathology. S3QEL 2 lowered HIF-1α induction, protected against ROS-induced, JNK-mediated cell stress in pancreatic beta-cells, and decreased the oxidative stress-induced apoptosis that limits the yield of functional β-cells from intact islets.

S3QEL 2, a cell permeable substituted allopurinol, is also known as 1-(3,4-Dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable