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SML1668

Sigma-Aldrich

Tipifarnib

≥98% (HPLC)

동의어(들):

(R)-(+)-R 115777, 6-[(R)-Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone, R115777

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1 MG
₹36,696.00

About This Item

실험식(Hill 표기법):
C27H22Cl2N4O
CAS Number:
192185-72-1
Molecular Weight:
489.40
MDL number:
MFCD07772347
UNSPSC 코드:
12352200
PubChem Substance ID:
329826003
NACRES:
NA.77

₹36,696.00

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도움 문의

Quality Level

100

분석

≥98% (HPLC)

양식

powder

광학 활성

[α]/D 17 to 24°, c = 1 in methanol

색상

white to beige

solubility

DMSO: 10 mg/mL, clear

저장 온도

−20°C

SMILES string

CN(C1=CC=C([C@](C2=CN=CN2C)(N)C3=CC=C(Cl)C=C3)C=C1C(C4=CC=CC(Cl)=C4)=C5)C5=O

InChI

1S/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3/t27-/m1/s1

InChI key

PLHJCIYEEKOWNM-HHHXNRCGSA-N

유사한 품목 비교

전체 비교 보기

차이점 표시

1 of 4

이 품목
SLW718242SLW718342SLW718234
Pyrex® Mortar 300 mL

SLW718247

Pyrex® Mortar

Pyrex® Mortar 120 mL

SLW718242

Pyrex® Mortar

Pyrex® Pestle rough finish, L 110 mm

SLW718342

Pyrex® Pestle

Pyrex® Mortar 100 mL

SLW718234

Pyrex® Mortar

manufacturer/tradename

718247, SciLabware

manufacturer/tradename

718242, SciLabware

manufacturer/tradename

718342, SciLabware

manufacturer/tradename

718234, SciLabware

capacity

300 mL

capacity

120 mL

capacity

-

capacity

100 mL

H

90 mm

H

75 mm

H

-

H

60 mm

O.D.

120 mm

O.D.

100 mm

O.D.

-

O.D.

80 mm

일반 설명

Pre-clinical studies show that tipifarnib has antiproliferative effects on pancreatic cancer cell lines at clinically relevant concentrations (concentration that inhibits 50% growth [IC50] from 9.5 to 500 nmol/L). It also exhibits marked growth retardation and antiangiogenic effects in a pancreatic cancer xenograft model.[1]

생화학적/생리학적 작용

Orally active and potent farnesyltransferase (FTase) inhibitor
Tipifarnib (R115777) is an orally active and potent farnesyltransferase (FTase) inhibitor that exhibits potent anti-tumorigenic effects. Tipifarnib mechanism of action is not fully understand.

픽토그램

Exclamation mark
GHS07

신호어

Warning

유해 및 위험 성명서

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number
096M4733V

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