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About This Item
실험식(Hill 표기법):
C9H14N2O2 · HCl
CAS Number:
Molecular Weight:
218.68
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
분석
≥97% (HPLC)
양식
powder
광학 활성
[α]/D -59 to -69°, c = 1.0 in methanol
저장 조건
desiccated
색상
white to beige
solubility
H2O: 2 mg/mL, clear
저장 온도
−20°C
SMILES string
O=C1O[C@@]2(CN1)CN3CCC2CC3.Cl
InChI
1S/C9H14N2O2.ClH/c12-8-10-5-9(13-8)6-11-3-1-7(9)2-4-11;/h7H,1-6H2,(H,10,12);1H/t9-;/m0./s1
InChI key
XGLBLUBBDSJBIU-FVGYRXGTSA-N
생화학적/생리학적 작용
AR-R17779 is a nicotinic acetylcholine receptor alpha7 full agonist that targets α7 nAChR with high affinity (Ki = 92 nM/rat α7 against 5 nM α-BTX vs.16 μM/rat α4β2 against 3 nM (-)-nicotine) and selectivity (EC50 = 6.2/10/12.7 μM using human/rat/monkey α7 nAChR-Xenopus oocyte by whole cell voltage clamp, no antagonistic activity against acetylcholine using human α4β2-, α3β4-, α3β2-, α3β2α5-expressing oocytes or antagonistic activity against 5-HT using rat 5HT3a-exxpressing oocytes). AR-R17779 exhibits cognition-improving efficacy in rats (1-20 mg/kg s.c) and mice (1-20 mg/kg i.p.) in vivo and is widely employed for studying other α7 nAChR-dependent physiological functions.
Selective high affinity nicotinic acetylcholine receptor alpha7 (α7 nAChR) full agonist with in vivo cognition-improving efficacy.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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