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About This Item
실험식(Hill 표기법):
C11H10FN3OS2
CAS Number:
Molecular Weight:
283.35
UNSPSC 코드:
41106609
NACRES:
NA.77
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
white to beige
solubility
DMSO: 2 mg/mL, clear
저장 온도
2-8°C
SMILES string
NC1=C(C(C2=CC=C(S2)F)=O)SC(NCC=C)=N1
InChI
1S/C11H10FN3OS2/c1-2-5-14-11-15-10(13)9(18-11)8(16)6-3-4-7(12)17-6/h2-4H,1,5,13H2,(H,14,15)
InChI key
GVYPHJQPOHDZEI-UHFFFAOYSA-N
생화학적/생리학적 작용
TAZ activator that promotes cardiomyocytes proliferation by activating YAP/TEAD-mediated transcription, as well as by exerting antioxidant and antiapoptotic activity.
TT-10 (TAZ K) is a TAZ (transcriptional coactivator with PDZ-binding motif) activator that promotes cardiomyocytes (CMs) proliferation (fold-increase by 10 μM TT-10 over untreated control = 5.2/rat CMs/40 hrs & 2.6/human iPSC-derived CMs/48 hrs) by activating YAP (YES-associated protein)/TEAD (transcriptional enhancer factor domain) complex-mediated transcription, as well as by exerting antioxidant and antiapoptotic activity. TT-10 ameliorates myocardial infarction-induced cardiac dysfunction in mice in vivo (10 mg/kg i.p.) at least in part via enhancing clonal expansion of existing cardiomyocytes with nuclear YAP expression.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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