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SML2755

Sigma-Aldrich

Netupitant

≥98% (HPLC)

동의어(들):

2-(3,5-bis(Trifluoromethyl)phenyl)-N,2-dimethyl-N-(6-(4-methylpiperazin-1-yl)-4-o-tolylpyridin-3-yl)propanamide, 2-[3,5-bis(Trifluoromethyl)phenyl]-N-[6-(4-methylpiperazin-1-yl)-4-o-tolylpyridin-3-yl]-N-methylisobutyramide, AGE 94200, AGE-94200, AGE94200, CID 6451149, CID-6451149, CID6451149, N,a,a-Trimethyl-N-[4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl]-3,5-bis(trifluoromethyl)benzeneacetamide, Ro 67-31898, Ro 67-31898/000

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크기 선택

500 TEST
CA$832.00

CA$832.00

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500 TEST
CA$832.00

About This Item

실험식(Hill 표기법):
C30H32F6N4O
CAS Number:
290297-26-6
Molecular Weight:
578.59
MDL number:
MFCD25976831
UNSPSC 코드:
12352200
NACRES:
NA.77

CA$832.00

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기술 서비스
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도움 문의

Quality Level

100

분석

≥98% (HPLC)

양식

powder

색상

white to beige

solubility

DMSO: 2 mg/mL, clear

저장 온도

2-8°C

SMILES string

FC(F)(F)c1cc(cc(c1)C(C)(C)C(=O)N(C)c2cnc(cc2c4c(cccc4)C)N3CCN(CC3)C)C(F)(F)F

InChI

1S/C30H32F6N4O/c1-19-8-6-7-9-23(19)24-17-26(40-12-10-38(4)11-13-40)37-18-25(24)39(5)27(41)28(2,3)20-14-21(29(31,32)33)16-22(15-20)30(34,35)36/h6-9,14-18H,10-13H2,1-5H3

InChI key

WAXQNWCZJDTGBU-UHFFFAOYSA-N

유사한 품목 비교

전체 비교 보기

차이점 표시

1 of 4

이 품목
HT5011HT5012HT501128
Zinc Formalin Fixative fixative, pH 6.2-6.3

Z2902

Zinc Formalin Fixative

Formalin solution, neutral buffered, 10% case of 48 × 15 mL, histological tissue fixative

HT5011

Formalin solution, neutral buffered, 10%

Formalin solution, neutral buffered, 10% case of 24 × 60 mL, histological tissue fixative

HT5012

Formalin solution, neutral buffered, 10%

Formalin solution, neutral buffered, 10% histological tissue fixative

HT501128

Formalin solution, neutral buffered, 10%

pH

6.2-6.3

pH

6.90-7.10

pH

6.90-7.10

pH

6.90-7.10

application(s)

hematology
histology

application(s)

hematology
histology

application(s)

hematology
histology

application(s)

hematology
histology

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

생화학적/생리학적 작용

Brain-penetrant, orally active, potent and selective neurokinin-1 (NK1) receptor (NK1R; Tachykinin receptor 1) antagonist with antiemetic efficacy in vivo.
Netupitant is a brain-penetrant, orally active, potent and selective neurokinin-1 (NK1) receptor (NK1R; Tachykinin receptor 1) antagonist (Ca+2 mobilization IC50 = 11.2 nM/hNK1 vs. >1 μM/rNK1 & hNK2/3; hNK1/2/3 Ki = 0.95 nM/1.6 μM/1.6 μM) that effectively blocks agonist GR73632-induced foot tapping in gerbils (ID50 = 0.5 mg/kg po 2h prior to 3 pmol/5 μL GR73632/gerbil icv). In addition to antiemetic efficacy against substance P-associated vomiting reflexes, netupitant is also reported to enhance the analgesic effects of electroacupuncture (EA) among humanized mice with sickle cell disease in response to pain in vivo (10 mg/kg/day, i.p.).

픽토그램

Exclamation mark
GHS07

신호어

Warning

유해 및 위험 성명서

H315,H319

예방조치 성명서

P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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