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Merck
모든 사진(1)

주요 문서

T5576

Sigma-Aldrich

TMPH hydrochloride

solid, (Product is pure based on CHN, NMR and MS results)

동의어(들):

2,2,6,6-Tetramethylpiperidin-4-yl heptanoate hydrochloride

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About This Item

실험식(Hill 표기법):
C16H32ClNO2
CAS Number:
Molecular Weight:
305.88
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77

Quality Level

양식

solid

저장 조건

under inert gas

색상

white

solubility

H2O: 22 mg/mL at ~60 °C

저장 온도

2-8°C

SMILES string

Cl.CCCCCCC(=O)OC1CC(C)(C)NC(C)(C)C1

InChI

1S/C16H31NO2.ClH/c1-6-7-8-9-10-14(18)19-13-11-15(2,3)17-16(4,5)12-13;/h13,17H,6-12H2,1-5H3;1H

InChI key

XIDDVJIJIFWGIX-UHFFFAOYSA-N

애플리케이션

Studies using TMPH have reported that it can alleviate the seizure-causing effect of levamisole. Additionally, it has been reported that TMPH does not induce behavioral changes in mice1.

생화학적/생리학적 작용

2,2,6,6-tetramethylpiperidin-4-yl heptanoate (TMPH) is a potent inhibitor of neuronal nicotinic receptors. Evaluation of nicotinic acetylcholine receptor (nAChR) subunits expressed in Xenopus laevis oocytes indicated that TMPH can produce a potent and long-lasting inhibition of neuronal nAChR formed by the pairwise combination of the most abundant neuronal alpha (i.e., alpha3 and alpha4) and beta subunits (beta2 and beta4), with relatively little effect, because of rapid reversibility of inhibition, on muscle-type (alpha1beta1gammadelta) or alpha7 receptors. However, the inhibition of neuronal beta subunit-containing receptors was also decreased if any of the nonessential subunits alpha5, alpha6, or beta3 were coexpressed. This decrease in inhibition is shown to be associated with a single amino acid present in the second transmembrane domain of these subunits. TMPH abilitty to relate the diverse central nervous system effects to specific nAChR subtypes makes it a useful tool for studying the functional roles of nAChR.
Noncompetitive inhibitor of neuronal nicotinic acetylcholine receptors; potent and long-lasting inhibitor of the most abundant nAhR subtypes (α3 or α4 plus β4) with little effect on muscle type (α1β1γδ) or α7 receptors; useful tool for studying the functional roles of nAChR.

특징 및 장점

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

제조 메모

TMPH hydrochloride is soluble in water at 22 mg/ml (at approx. 60° C).

픽토그램

Exclamation mark

신호어

Warning

유해 및 위험 성명서

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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