T7883

Trimethoprim

≥98.5%

• 동의어(들): 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine, NSC 106568
• 실험식(Hill 표기법): C₁₄H₁₈N₄O₃
• CAS Number: 738-70-5
• Molecular Weight: 290.32
• Beilstein: 625127
• EC Number: 212-006-2
• MDL number: MFCD00036761
• UNSPSC 코드: 51285203
• PubChem Substance ID: 24278201
• NACRES: NA.85

속성

• Quality Level: 200
• 분석: ≥98.5%
• 양식: powder
• 저장 조건: (Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
• 색상: white to light yellow
• 항생제 활성 스펙트럼: Gram-negative bacteria; Gram-positive bacteria; mycobacteria
• 동작 모드: DNA synthesis | interferes; enzyme | inhibits
• 저장 온도: 2-8°C
• SMILES string: COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
• InChI: 1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
• InChI key: IEDVJHCEMCRBQM-UHFFFAOYSA-N
• 유전자 정보: human ... DHFRP1(573971), KCNH1(3756) ; rat ... Dhfr(24312)

설명

일반 설명

Chemical structure: pyrimidine

애플리케이션

Primarily used as an antibacterial agent. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.

Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections.

생화학적/생리학적 작용

The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.

포장

5G,25G,100G

기타 정보

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H361d
• 예방조치 성명서: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)