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About This Item
실험식(Hill 표기법):
C23H15NO3
CAS Number:
Molecular Weight:
353.37
MDL number:
UNSPSC 코드:
12352202
PubChem Substance ID:
NACRES:
NA.77
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
yellow
solubility
DMSO: >2 mg/mL
저장 온도
2-8°C
SMILES string
COc1ccc(cc1)-c2cnc(o2)-c3cccc4C(=O)c5ccccc5-c34
InChI
1S/C23H15NO3/c1-26-15-11-9-14(10-12-15)20-13-24-23(27-20)19-8-4-7-18-21(19)16-5-2-3-6-17(16)22(18)25/h2-13H,1H3
InChI key
SVICLWPFAQYZLX-UHFFFAOYSA-N
유사한 제품을 찾으십니까? 방문 제품 비교 안내
생화학적/생리학적 작용
Studies have also reported that UA62784 associates with tubulin at or near the colchicine-binding sites in cells and functions as a cytotoxic, microtubule inhibitor.
UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor.
UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly.
제조 메모
UA62784 is soluble in DMSO at a concentration >2 mg/ml.
신호어
Warning
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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