UC430

1′-Hydroxymidazolam

≥97% (HPLC), powder

• 동의어(들): 8-Chloro-6-(2-fluorophenyl)-1-hydroxymethyl-4H-imidazo[1,5a][1,4]benzodiazepine
• 실험식(Hill 표기법): C₁₈H₁₃ClFN₃O
• CAS Number: 59468-90-5
• Molecular Weight: 341.77
• MDL number: MFCD00871458
• UNSPSC 코드: 12161501
• PubChem Substance ID: 24724655
• NACRES: NA.77

속성

• Product Name: 1′-Hydroxymidazolam,
• 양식: powder
• Quality Level: 200
• 약물 제어: regulated under CDSA - not available from Sigma-Aldrich Canada
• 색상: white to off-white
• 저장 온도: 2-8°C
• SMILES string: OCc1ncc2CN=C(c3ccccc3F)c4cc(Cl)ccc4-n12
• InChI: 1S/C18H13ClFN3O/c19-11-5-6-16-14(7-11)18(13-3-1-2-4-15(13)20)22-9-12-8-21-17(10-24)23(12)16/h1-8,24H,9-10H2
• InChI key: QHSMEGADRFZVNE-UHFFFAOYSA-N

설명

일반 설명

1′-Hydroxymidazolam is the metabolite of midazolam.

애플리케이션

1′-Hydroxymidazolam (1′-OHMDZ) can be used for assessing Cyp3a11 enzyme activity as well as for pharmacokinetic (PK) study of midazolam.

CYP3A4 metabolite of midazolam.

생화학적/생리학적 작용

1′-Hydroxymidazolam is the major hydroxylated metabolite of Midazolam (MDZ), forms due to rapid and extensive metabolization of MDZ by the CYP 450 3A isoenzymes in the liver. The product contributes to the pharmacological impact of MDZ.

특징 및 장점

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포장

Bottomless glass bottle. Contents are inside inserted fused cone.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)