1148090

Collagenase II

United States Pharmacopeia (USP) Reference Standard

• 동의어(들): Collagenase from Clostridium histolyticum, Clostridiopeptidase A
• CAS Number: 9001-12-1
• EC 번호: 3.4.24.3 (BRENDA, IUBMB)
• MDL number: MFCD00130830
• UNSPSC 코드: 41116107
• NACRES: NA.24

속성

• Grade: pharmaceutical primary standard
• 양식: liquid
• 제조업체/상표: USP
• 응용 분야: pharmaceutical
• 형식: neat
• 저장 온도: −70°C

설명

일반 설명

Collagenase II is another form of collagenase enzyme with specificity for different types of collagen. It is utilized similarly to Collagenase I in tissue dissociation and other applications requiring collagen degradation.​

The USP Collagenase II standard ensures the quality and activity of this enzyme, providing a reliable reference for its use in research and clinical applications.

The USP biologics proteins category provides critical standards and reference materials necessary for the development and manufacturing of therapeutic proteins. These proteins, which can be naturally derived or genetically engineered, are essential in treating various diseases and conditions, ensuring that they meet quality, safety, and efficacy standards.

The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.

생화학적/생리학적 작용

Collagenase is activated by four gram atom calcium per mole enzyme. It is inhibited by ethylene glycol-bis(beta-aminoethyl ether) - N, N, N′,N′-tetraacetic acid, beta-mercaptoethanol, glutathione, thioglycolic acid and 8-hydroxyquinoline.

단위 정의

One collagen digestion unit (CDU) liberates peptides from collagen from bovine achilles tendon equivalent in ninhydrin color to 1.0 μmole of leucine in 5 hours at pH 7.4 at 37 °C in the presence of calcium ions. One FALGPA hydrolysis unit hydrolyzes 1.0 μmole of furylacryloyl-Leu-Gly-Pro-Ala per min at 25°C. One Neutral Protease unit hydrolyzes casein to produce color equivalent to 1.0 μmole of tyrosine per 5 hr at pH 7.5 at 37°C. One Clostripain Unit hydrolyzes 1.0 μmole of BAEE per min at pH 7.6 at 25°C in the presence of DTT.

분석 메모

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

기타 정보

This product is part of the USP Biologics program.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H334
• 예방조치 성명서: P261 - P284 - P501
• Hazard Classifications: Resp. Sens. 1
• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable