333115

2-Isopropylmalic acid

98%

• Synonym(s): 2-Hydroxy-2-isopropylsuccinic acid
• Linear Formula: HO₂CCH₂C[CH(CH₃)₂](OH)CO₂H
• CAS Number: 3237-44-3
• Molecular Weight: 176.17
• MDL number: MFCD00075003
• UNSPSC Code: 12352100
• PubChem Substance ID: 24860103
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 98%
• mp: 144-146 °C (lit.)
• functional group: carboxylic acid; hydroxyl
• SMILES string: CC(C)C(O)(CC(O)=O)C(O)=O
• InChI: 1S/C7H12O5/c1-4(2)7(12,6(10)11)3-5(8)9/h4,12H,3H2,1-2H3,(H,8,9)(H,10,11)
• InChI key: BITYXLXUCSKTJS-UHFFFAOYSA-N

Description

General description

2-Isopropylmalic acid is an intermediate formed during leucine biosynthesis. Budding yeast Saccharomyces cerevisiae secrets 2-isopropylmalic acid and helps in reduction of aluminum toxicity by forming chelate with Al ions, thereby preventing them from entering the cells.

Application

2-Isopropylmalic acid was employed as an internal standard in diagnostic model for pancreatic cancer using GC/MS-based human serum metabolomics.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves