349593

6-Fluoroindole

98%

• Synonym(s): NSC 520436
• Empirical Formula (Hill Notation): C₈H₆FN
• CAS Number: 399-51-9
• Molecular Weight: 135.14
• Beilstein: 112192
• MDL number: MFCD00056933
• UNSPSC Code: 12352100
• PubChem Substance ID: 24861689
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 98%
• mp: 72-76 °C (lit.)
• functional group: fluoro
• SMILES string: Fc1ccc2cc[nH]c2c1
• InChI: 1S/C8H6FN/c9-7-2-1-6-3-4-10-8(6)5-7/h1-5,10H
• InChI key: YYFFEPUCAKVRJX-UHFFFAOYSA-N

Description

General description

6-Fluoroindole is a halogen substituted indole. Experimental ionization potential of 6-fluoroindole has been evaluated. Preparation of 6-fluoroindole via nitration of indoline has been reported.

Application

6-Fluoroindole may be used as reactant in the preparation of:

• tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators
• antibacterial agents
• antifungal agents
• Sodium-Dependent Glucose Co-transporter 2 (SGLT2) Inhibitors for the management of hyperglycemia in diabetes
• potent selective serotonin reuptake inhibitors
• inhibitors of HIV-1 attachment

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves