Sign Into View Organizational & Contract Pricing
About This Item
Linear Formula:
COCl2
CAS Number:
Molecular Weight:
98.92
Beilstein:
1098367
MDL number:
UNSPSC Code:
12352101
PubChem Substance ID:
NACRES:
NA.22
form
liquid
Quality Level
concentration
15 wt. % in toluene
density
0.924 g/mL at 25 °C
functional group
chloro
storage temp.
2-8°C
SMILES string
ClC(Cl)=O
InChI
1S/CCl2O/c2-1(3)4
InChI key
YGYAWVDWMABLBF-UHFFFAOYSA-N
Looking for similar products? Visit Product Comparison Guide
General description
Phosgene is used as a reagent in organic synthesis for various reactions such as carbonylation reaction and synthesis of isocyanates. Phosgene is formed during the free radical induced degradation of chlorinated hydrocarbons. Determination of phosgene in air samples using thermal desorption (TD) followed by gas chromatography-mass spectrometry (GC-MS) has been reported.
Application
Phosgene solution (15 wt. % in toluene) has been used to synthesize the following peptide monomers:
- γ-(4-propargyloxybenzyl)-L-glutamic acid N-carboxyanhydride (POB-L-Glu-NCA)
- γ-(4,5-dimethoxy-2-nitrobenzyl)-L-glutamate N-carboxyanhydride (DMNB-L-Glu-NCA)
- γ-(4,5-dimethoxy-2-nitrobenzyl)-D-glutamate N-carboxyanhydride (DMNB-D-Glu-NCA)
- 2-nitrobenzyl(4-vinylphenyl)carbamate
Phosgene solution may be used in the synthesis of:
- sulfonyl chlorides
- Fmoc (Fluorenylmethyloxycarbonyl chloride)-taurylsulfonyl chloride
- O-benzyl-L-serine carboxyanhydrides
Packaging
The 25 mL Sure/Seal™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.
Legal Information
Sure/Seal is a trademark of Sigma-Aldrich Co. LLC
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 1 Inhalation - Aquatic Chronic 3 - Asp. Tox. 1 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2 - Skin Corr. 1B - STOT RE 2 - STOT SE 3
Target Organs
Central nervous system
Storage Class Code
3 - Flammable liquids
WGK
WGK 3
Flash Point(F)
39.2 °F - closed cup
Flash Point(C)
4 °C - closed cup
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service