Voltage-gated sodium channel subunit alpha Nav1.7 (Nav1.7) is a multi-pass membrane protein containing a single IQ domain that belongs to the sodium channel family. NAV1.7 localizes to the terminal ends of sensory neurons and is believed to have a role in inflammatory pain development and mechanisms. It serves to regulate excitable membrane voltage-dependent Na+ ion permeability. There is a strong probability that Nav1.7 is involved in the transmission of nociceptive information, a suggested involvement supported by its role in a variety of chronic pain neuropathies induced by damage to the peripheral nerves. Nav1.7 is predominantly observed in dorsal root ganglion, and sensory and sympathetic neurons. Lower levels of the protein have been observed in MTC cell line, C-cell carcinoma, and smooth muscle cells. Defects in Nav1.7 expression are causal to several diseases such as autosomal recessive congenital indifference pain, primary erythermalgia, and paroxysmal extreme pain disorder or PEPD.

Recombinant protein corresponding to human Nav1.7.

Research Category
Neuroscience

Signaling

Research Sub Category
Signaling Neuroscience

This Anti-Sodium channel Nav1.7 Antibody, clone N68/6 is validated for use in IH, WB for the detection of Sodium channel Nav1.7.

Western Blot Analysis: A previous lot was used by an independent laboratory in HEK293 cell lysate. (James Trimmer, UC Davis/NIH NeuroMab Facility, Department of Neurobiology, Physiology and Behavior, UC Davis, Davis CA 95616-8519. neuromab@ucdavis.edu.)

Evaluated by Immunohistochemistry in rat cerebellum tissue.

Immunohistochemistry Analysis: 1:400 dilution of this antibody detected Nav1.7 in rat cerebellum tissue.

Observed at ~ 230 kDa

Format: Purified

Protein G

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
Rat cerebellum tissue

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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