I4386
Iodoacetic acid
≥98.0% (T)
Synonym(s):
2-Iodoacetic acid
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10 MG
₩207,162
About This Item
Linear Formula:
ICH2CO2H
CAS Number:
Molecular Weight:
185.95
Beilstein:
1739079
EC Number:
MDL number:
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
biological source
synthetic
Quality Level
Assay
≥98.0% (T)
form
powder or flakes
color
white to yellow
mp
77-79 °C (lit.)
solubility
H2O: soluble, clear to hazy
storage temp.
−20°C
SMILES string
OC(=O)CI
InChI
1S/C2H3IO2/c3-1-2(4)5/h1H2,(H,4,5)
InChI key
JDNTWHVOXJZDSN-UHFFFAOYSA-N
Application
Iodoacetic acid has been used as an alkylating agent for antibody AR37,[1] serum proteins[2] and strawberry proteome samples extracted from different stages of ripened fruit.[3]
Reagent for the modification of cysteine residues in proteins.
Biochem/physiol Actions
Iodoacetic acid (IAA) blocks the thiol group of cysteine.[4] IAA inhibits glyceraldehyde-3-phosphate dehydrogenase (G3PDH) by interacting with sulfhydryl group of the active site cysteine. IAA inhibits the progression of solid Ehrlich carcinoma.[5] IAA is one of the iodinated disinfection byproducts in drinking water. It is cytotoxic to mammalian cells.[6]
1 of 4
This Item | SYNPLE-BT022 | SYNPLE-BT033 | SYNPLE-BT023 |
|---|---|---|---|
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| parameter up to 0.1 mmol scale | parameter up to 0.1 mmol scale | parameter up to 0.1 mmol scale | parameter up to 0.1 mmol scale |
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Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral - Eye Dam. 1 - Skin Corr. 1A
Storage Class Code
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Benoit Pilmis et al.
Medecine sciences : M/S, 29 Spec No 1, 25-30 (2013-05-15)
Mucormycosis is a life-threatening invasive fungal infection that arises among immunocompromised patients (haematological malignancies, solid organ transplantation, diabetes mellitus). The most frequent sites of infection are pulmonary, rhinocerebral, cutaneous and disseminated. Reversal of the underlying conditions is mandatory for controlling
Bao Zhang et al.
Biochimica et biophysica acta, 1828(9), 2230-2237 (2013-06-13)
Bacillomycin L, a natural iturinic lipopeptide produced by Bacillus amyloliquefaciens, is characterized by strong antifungal activities against a variety of agronomically important filamentous fungi including Rhizoctonia solani Kühn. Prior to this study, the role of membrane permeabilization in the antimicrobial
Anil Bhansali et al.
The Journal of the Association of Physicians of India, 60, 54-58 (2013-06-20)
Histoplasmosis has been sporadically reported from India. Though asymptomatic adrenal involvement has been described in patients with disseminated histoplasmosis; isolated adrenal involvement with adrenal insufficiency (AI) as the presenting manifestation of the disease is rare. We describe 5 immunocompetent men
