Iodine monochloride is an interhalogen compound. It forms various complexes with ethyl, isopropyl and t-butylbenzenes. Equilibrium constants for the formation of these complexes have been evaluated. It affords electrically conducting solution on dissolution in polar solvents. Its reaction with thymidine, 3-mono- and 3,3′,5′-trialkylsubstitued thymidine showed that it helps in deglycosylation, anomerization and isomerization of thymidine.

Iodine monochloride (ICl) may be employed for the halogenation of methoxy and dimethoxybenzenes. It may be used for the synthesis of flavones.

Iodine monochloride may be used in the synthesis of the following:

• 2-(4-haloisoquinolin-1-yl)ethanol derivatives
• 5-iodosalicylaldehydes
• 5-aryl-6-iodo-8-phenylpyrazolo[1,5-c]-1,2,4-triazolo[4,3-a]pyrimidines
• (±)-1-cyclohexyl-4-iodo-3-methoxybutan-1-ol
• (±)-4-Iodo-3-methoxy-1-phenylbutan-1-ol