455180

Hydrogen chloride solution

2.0 M in diethyl ether

• Empirical Formula (Hill Notation): HCl
• CAS Number: 7647-01-0
• Molecular Weight: 36.46
• MDL number: MFCD00011324
• UNSPSC Code: 12352301
• PubChem Substance ID: 329756805
• NACRES: NA.21

Properties

• form: liquid
• Quality Level: 100
• concentration: 1.90-2.20 M (with NaOH, titration); 2.0 M in diethyl ether
• bp: 34.6 °C
• density: 0.747 g/mL at 25 °C
• storage temp.: 2-8°C
• SMILES string: Cl
• InChI: 1S/ClH/h1H
• InChI key: VEXZGXHMUGYJMC-UHFFFAOYSA-N

Description

General description

Hydrogen chloride solution contains 2M hydrogen chloride in diethyl ether as the solvent. It is a strong acid and highly corrosive in nature and is commonly used in the selective cleavage of the protecting groups 2,4,6-trimethoxyphenyl from the respective (2,4,6-trimethoxyphenyl)silane to produce chlorosilanes.

Application

Hydrogen chloride solution can be used as a reagent to synthesize:

• Cyanohydrin alkyl ethers via chiral Bronsted acid-mediated hydrocyanation of vinyl ethers with silyl cyanides.
• N, N-Dimethylaniline hydrochloride salts via Pd-catalyzed Buchwald-Hartwig amination of aryl triflates with dimethylamines.

It can also be used as a catalyst for the amidation of carboxylic acids with amines to synthesize amides.

Safety Information

• Pictograms: GHS02,GHS06,GHS05
• Signal Word: Danger
• Hazard Statements: H224,H290,H302,H331,H336,H412
• Precautionary Statements: P210 - P233 - P273 - P301 + P312 - P304 + P340 + P311 - P403 + P233
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Flam. Liq. 1 - Met. Corr. 1 - STOT SE 3
• Target Organs: Central nervous system
• Supplementary Hazards: EUH019,EUH066
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): -29.2 °F - closed cup
• Flash Point(C): -34 °C - closed cup