94310
Uricase from Bacillus fastidiosus
lyophilized, ~9 U/mg
Synonym(s):
Urate oxidase
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About This Item
biological source
Bacillus sp. (B. fastidiosus)
Quality Level
form
powder
quality
lyophilized
specific activity
~9 U/mg
storage condition
dry at room temperature
concentration
90—100%
color
white to faint beige
solubility
5 mg/mL, clear, colorless to very faintly yellow (in enzyme dilution buffer)
application(s)
detection
General description
Research area: Cell signaling
Uricase is present in many organisms, such as, archaea, bacteria, and eukaryotes. The Gut microbiome is the major source of uricase, a homotetrameric enzyme containing four identical 34 kDa subunits.
Application
Uricase may be used for the determination of uric acid in biological fluids. It may be helpful in the spectrophotometric determination of purines and purine nucleosides.
Biochem/physiol Actions
Uricase catalyzes the oxidation of uric acid to 5-hydroxyisourate, which subsequently forms (S)-allantoin. It is involved in purine metabolism, urate degradation and (S)-allantoin formation The absence of functional uricase in humans has significant physiological and pathophysiological implications. It has been associated with higher serum uric acid levels, leading to an increased risk of conditions related to uric acid crystallization, such as gout. Uricase has emerged as an important therapeutic target for the treatment of conditions related to hyperuricemia, such as gout.
Unit Definition
1 U corresponds to the amount of enzyme which oxidizes 1 μmole uric acid at pH 9.1 and 37 °C.
Other Notes
For the determination of uric acid in biological fluids; In the spectrophotometric determination of purines and purine nucleosides.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Repr. 1B - Resp. Sens. 1
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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