Name: R(+)-SCH-23390 hydrochloride
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₈ClNO · HCl

CAS Number:

125941-87-9

Molecular Weight:

324.24

MDL number:

MFCD00069249

UNSPSC Code:

12352200

PubChem Substance ID:

24277910

NACRES:

NA.77

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Quality Level

100

Assay

≥98% (HPLC)

form

solid

optical activity

[α]/D +32.1°, c = 1 in DMF(lit.)

storage condition

desiccated
protect from light

color

white

solubility

H₂O: >5 mg/mL

SMILES string

Cl[H].CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c3ccccc3

InChI

1S/C17H18ClNO.ClH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H/t15-;/m1./s1

InChI key

OYCAEWMSOPMASE-XFULWGLBSA-N

Gene Information

human ... DRD1(1812)

Application

R(+)-SCH-23390 hydrochloride has been used:

for intraperitoneal injection into experimental rats to study the role of D1 receptor in sensitization
as a D1 receptor-selective antagonist for intracranial drug infusions
as an antagonist of D1 receptor to study its effect on learning ability in fish

Biochem/physiol Actions

R(+)-SCH-23390 hydrochloride is a selective D1 dopamine receptor antagonist. It has greater binding capacity towards 5-hydroxytryptamine 2 (5-HT2) and 5-HT1C serotonin receptor subtypes in in vitro. R(+)-SCH-23390 has a half-life of about 25 minutes after administration. It is known to possess anti-stereotypic effect and cataleptogenic effect. It also has inhibitory effect on motor activity.

Features and Benefits

This compound is featured on the Dopamine Receptors and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Sold with the permission of Schering-Plough.

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Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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