Name: (<I>R</I>)-(+)-SKF-38393 hydrochloride
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₇NO₂ · HCl

CAS Number:

81702-42-3

Molecular Weight:

291.77

MDL number:

MFCD00055189

UNSPSC Code:

12352200

PubChem Substance ID:

329824192

NACRES:

NA.77

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Quality Level

100

Assay

≥98% (HPLC)

form

solid

optical activity

[α]22/D +16.1°, c = 1.2 in methanol(lit.)

storage condition

desiccated

color

off-white to light tan

solubility

0.1 M HCl: 1.2 mg/mL
ethanol: 3.4 mg/mL
H₂O: 5 mg/mL
aqueous base: unstable

SMILES string

Cl.Oc1cc2CCNC[C@H](c3ccccc3)c2cc1O

InChI

1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H/t14-;/m1./s1

InChI key

YEWHJCLOUYPAOH-PFEQFJNWSA-N

Application

(R)-(+)-SKF-38393 hydrochloride has been used as a D1 dopamine receptor agonist to study its effect on the sleep-wake pattern of macaques rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

Biochem/physiol Actions

(R)-(+)-SKF-38393 hydrochloride is a D1 dopamine receptor agonist and an active enantiomer of (±)-SKF-38393. It enhances pertussis toxin-insensitive and protein kinase A-mediated glutamate release in the hippocampal neurons. SKF-38393, a benzazepine derivative, exhibits anorectic effects.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Caution

Light sensitive

Reconstitution

Solutions may be stored for several days at 4 °C.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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